Fly from Istanbul to Izmir.Transfer fro the airport and drive to Bergama. Arrive in the ancient city of Pergamon and visit the Acropolis. Following a lunch break, visit the Asclepion, a highly significant medical center in the ancient world. A final stop-off is at a local handicraft co-operative in Bergama. Then drive back to Izmir. Overnight in Izmir.
Drive to Selcuk. Visit the remains of the Artemis Temple, one of the seven wonders of the ancient world. Next, proceed to the spectacular site of Ephesus, undoubtedly the most superbly preserved Greco-Roman city. Following a lunch break, visit the House of Virgin Mary; reputed to be where she spent her final days. Later, visit the old Seljuk Mosque of Isabey. Return to Izmir. Overnight in Izmir.
Transfer to Izmir airport. Fly to Istanbul. Transfer to your hotel.